Addressing the alarming rise of the bacterium "Mycobacterium avium Paratuberculosis"
in the environment and the growing evidence linking this bacterium to Crohn's
disease.

                           


Crohn'sCanada

      

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Founders: Diane and Michael Fagen

Contact Info: dianef84@yahoo.com

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Health of Animals Act, SC 1990, c 21

List of Reportable Diseases and REGULATIONS PRESCRIBING CERTAIN DISEASES AS REPORTABLE DISEASES

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La Presse,  April 8, 2001,  Never in My Milk? by Marie France Coutu

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Taking Action

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Does Mycobacterium Paratuberculosis cause Crohn's disease by Alan Kennedy  

(PARA) PARATUBERCULOSIS AWARENESS & RESEARCH ASS.,INC



Shafran's Gasterology Center

The Johne's Information Center

History of Early Research on Crohn's disease

Dr. B. Crohn

Got Milk? by Michael Greger, MD Updated January 2001

THE CROHN'S CONNECTION  by Lisa Chamberlain

Dire Warnings About Johne’s
Disease A wake-up call for the dairy industry?

Micobacteria and Crohn's Disease

Dr. Chiodini's Tables

American and European Links

University of Wisconsin School of Veterinary Medicine

Health Canada

Action Medical Research

 

University of Guelph

NACC

 

 
 

 

 

Medical News Today: Food bug toxin may trigger multiple sclerosis
New research presented at a scientific meeting adds to a growing body of evidence that a toxin produced by a common food bug may trigger multiple sclerosis, an inflammatory disease of the central nervous system.
Also see additionnal updates on my website

 

Is a cure for Crohn's disease in sight?by Kathleen Blanchard, January 30, 2014

In a press release, published September, 2013, Naser announced a Phase III clinical trial that uses an antibiotic that removes a bacterium thought to cause Crohn's disease inflammation.

Researchers uncover genetic link to cattle diseases, April 17, 2013 3:00 am • By Sandra Avant, ARS News Service(0) Comments Detecting the costly, contagious Johne's disease in cattle is now easier, thanks to U.S. Department of Agriculture (USDA) scientists.

 

How to get help with Crohn’s Disease Posted on November 8, 2012 by Judith Eve Lipton M.D.      To People with Crohn’s Disease     I receive many letters from people around the world asking about treating Crohn’s with antibiotics, under the theory that Crohn’s disease is an infection caused by MAP, mycobacterium avium subspecies paratuberculosis. I am a psychiatrist, not a GI doctor, and not qualified to make specific suggestions about treating Crohn’s disease in specific cases.

 

Could a vaccine help Crohn's disease? by MARTYN HALLE, Daily Mail Read more: Researchers have made a major medical breakthrough by developing a vaccine against the crippling digestive illness Crohn's disease. More than 100,000 people in the UK are stricken by the condition, which causes a chronic inflammation of the intestine. Professor John Hermon-Taylor of St George's Hospital, London, has developed a vaccine which should be ready within the next five years. Read more: http://www.dailymail.co.uk/health/article-15442/Could-vaccine-help-Crohns-disease.html#ixzz2hMihbzOb Follow us: @MailOnline on Twitter | DailyMail on Facebook

 

Crohn's Vaccine Appeal: Professor John Hermon-Taylor of Saint George's, University of London, is appealing for help to fund the final stages of development of a new Crohn's vaccine, which is now ready to proceed to human clinical trials.      How you can help  To help raise the funds needed to develop this treatment, you can make a donation directly to St George's. Cheques can be made payable to St George's University of London, with the reference CROHNS A/C RLB0057 on the back. Send your donation to: Professor John Hermon-Taylor St George's University of London Cranmer Terrace LONDON, SW17 0RE St George's, University of London is a Tax Exempt Charity No: X66491. All donations received are used for research. For further information on SGUL please contact Mark Bery, SGUL Finance Director, on +44 020 8725 5024 or mbery@sgul.ac.uk. You can also help by signing the online petition to the government for funding.

 

10.1128/AEM.02719-12. Appl. Environ. Microbiol. 2013, 79(5):1612. DOI: Hoffman and Osvaldo Jorge Lopez Silvia Leonor Mundo, Liliana Rosa Gilardoni, Federico José Methylase Genotyping paratuberculosis in Cow's Milk by DNA Mycobacterium avium subsp. R

 

Received August 18, 1989.         Sequence and characteristics or IS900, an insertion element identified in a human Crohn's disease isolate or Mycobacterium paratuberculosis E.P. Green*, M.L.V. Tizard, M.T. Moss, J. Thompson, D.J. Winterbourne, J.J. McFadden+ and J. Hermon-Taylor

 

Faculty of health and medical sciences university of copenhagen       PHD tHesis 2013 · Hisako okura assessment of Mycobacterium avium subsp. paratuberculosis in milk and beef from Danish cattle

 

ISRN Veterinary Science Volume 2013 (2013), Article ID 323671, 4 pages    Detection of Mycobacterium avium Subspecies Paratuberculosis from Intestinal and Nodal Tissue of Dogs and Cats

 

Gut Pathog. 2013; 5: 18.   Molecular identification of Mycobacterium avium subspecies paratuberculosis in oral biopsies of Crohn’s disease patients Paola Molicotti,corresponding author#1 Antonio M Scanu,#2 Aurea Lumbau,3 Sara Cannas,1 Alessandra Bua,1 Pietrina Lugliè,3 and Stefania Zanetti1

 

YouTube: Qu Biologics SSI vaccine puts me into complete Crohns remission

 

Youtube Testamonials re QBECO SSI treatement 100 percent clinical remission

 

QBECO SSI Efficacy & Safety QBECO for the treatment of Crohn’s disease

 

May 28, 2013:   ScienceDaily, Changing Gut Bacteria Through Diet Affects Brain Function

 

New Society Publishers Blog

 

Book called WhiteWash written by John Robbins, son of famous founder of Baskin Robbins icecream

 

The Most Important Disease You Probably Never Heard Of December 31, 2010, 12:50 pm By David Barash

 

 

Dairy and Crohn’s disease: Is there a link? Sam Herron Anilec Vita, Staff Writer November 7, 2012 Filed under Health & Lifestyle, Top Stories
Johne’s disease produces similar symptoms in animals as Crohn’s disease does in humans. It is argued by some that MAP bacteria can be transmitted from cows to humans through meat or dairy products. However, this theory has yet to be proven. One of the advocates of this theory is Dr. Lester Friedlander, doctor of veterinary medicine, and former U.S. Department of Agriculture chief inspector of the largest cow slaughter plant in the United States. Friedlander has been warning Americans about the presence of MAP bacteria in milk and meat for more than a decade. According to Friedlander, around 70 percent of the dairy herds in the U.S. are infected with Johne’s disease, creating a menace for consumers, because the bacteria can survive pasteurization. Friedlander also states that cows infected with Johne’s disease are being slaughtered for human consumption, and that the USDA allows it even if it is against their regulation. “As a USDA inspector, I had to make sure that the animals for human consumption were healthy and disease free,” Friedlander says. “But these cows came with a veterinarian service form, VS-127, and were infected with Johne’s.”

 

Johne's Disease in cattle and Crohn ’ s Disease in humans – linked diseases? University of Calgary, Herman Barkema, Mariá Negrón, Kevin Rioux, Jeroen De Buck, Karin Orsel, Subrata Ghosh and Gilaad Kaplan Alberta Inflammatory Bowel Disease Consortium

Crohn's Disease and Mycobacterium Paratuberculosis A Bacteria That Infects Cattle May Have A Role In Crohn's Disease By Amber J. Tresca, About.com Guide Updated April 13, 2012

 

November 2012 How to get help with Crohn’s Disease by Dr Judith Eve Lipton

 

Action Medical Research: This organisation has been a constant support to Prof.John Hermon - Taylor and has given £159.700 to St Georges Hospital for The New DNA Crohns Vaccine Over 4 Years Ago.

 

September 2012 U.S. Library Of Medicine:Mycobacterium avium subsp. paratuberculosis Inhibits Gamma Interferon-Induced Signaling in Bovine Monocytes: Insights into the Cellular Mechanisms of Johne's Disease

 

September 2012- Youtube Video: Super Synbiotic Probiotics - John Ellerman.....Comprehensive conference call with John Ellerman, Micro-Biologist & Scientific Probiotic Cultures expert on the uses and benefits of Pro-biotics in supporting intestinal health which is related to a whole plethora of other conditions. .............................................................. ,,,,,,,,,,Neways: Lacto-Flora™ Super symbiotic pre and probiotic concentrate: There are literally trillions of bacteria living inside your intestines – and most of them are essential to your wellbeing! These bacteria can be broadly divided into two categories, and while it may be tempting to simply think of them as ‘good and bad’ it’s more accurate to view them as those which are beneficial to our health and those which can be potentially detrimental to our health. Those bacteria which are beneficial to our health are commonly referred to as probiotics and they play a huge role in our health and wellbeing. The beneficial bacteria perform many useful functions including fermenting indigestible carbohydrates, producing B-group vitamins and vitamin K and helping to maintain or enhance optimal digestive function. However, when the balance of bacteria in the gut is upset the corresponding rise in the amount of potentially harmful bacteria can lead to digestive disturbances and other illnesses. The balance of bacteria can be negatively influenced by alcohol intake; consumption of processed, fast and fatty foods; stress; antibiotics; as well as medication such as the oral contraceptive pill. When this occurs, a quality supply of probiotic bacteria can help to restore a proper bacterial balance within the digestive system.

 

Crohn's Disease and Mycobacterium Paratuberculosis A Bacteria That Infects Cattle May Have A Role In Crohn's Disease By Amber J. Tresca, About.com Guide Updated April 13, 2012

April 2012!!!!!!!!! Canadian Consumer Raw Milk Advocacy Group: Keep in mind as you read this that the majority of countries where raw milk is legal require testing for MAP infected cows before their milk is ever allowed for sale. In Canada, the group Cow Share Canada, requires it’s farmers to have each and every one of their cows tested for this before they are allowed to even come onto the farm. As of this writing, there seems to be no obligation for a farmer supplying milk to be pasteurized, to have his cows tested. Once all that milk is in a common bulk tank headed for the pasteurizing plant how do we know if it’s infected or not?

 

January 2012 Pubmed: Vitamins A & D inhibit the growth of mycobacteria in radiometric culture.Proper vitamin D–vitamin A ratio Robert from California writes: Dr. Cannell replies, don't know if copyright laws allow the author to do that, but I will take the chance. The crux of the problem is that a form of vitamin A, retinoic acid, weakly activates the vitamin D response element on the gene and perhaps blocks vitamin D's more robust activation. In fact, the authors of a 1993 study state "there is a profound inhibition of vitamin D-activated...gene expression by retinoic acid."

Crohn's Forum: Welcome to the Crohn's Disease Forum - Support group and forum for Crohn's Disease, Ulcerative Colitis, and other IBD

Center for Digestive Diseases: Anti-MAP. The bacterium, Mycobacterium avium paratuberculosis (MAP), is an infectious cause of Crohn’s Disease. Its causality has been proven by the standard Koch’s postulates which have been fulfilled by culturing the pathogen from patients with Crohn’s Disease, causing the disease to be reproduced in experimental animals, and then culturing back the bacterium from the experimental animals. Hence, a subset of patients with Crohn’s Disease – estimated to be around 50% - are suffering from this chronic inflammation caused by infection with MAP which is found in milk, water and foods generally.

ResearchGate: May 2011, Occurrence of Mycobacterium avium subsp. paratuberculosis in raw water and water treatment operations for the production of potable water. G Aboagye, M T Rowe Food Microbiology, The Queen's University of Belfast, Belfast, Northern Ireland, United Kingdom.

ResearchGate: February 2011, Detection of Mycobacterium avium ssp. paratuberculosis in cheese, milk powder and milk using IS900 and f57-based qPCR assays. J A Donaghy, J Johnston, M T Rowe Agri-Food and Biosciences Institute (AFBI), AFESD, Newforge Lane, Belfast, UK.

January 2011 Pubmed: Serum antibodies to Mycobacterium avium subspecies paratuberculosis combined with anti-Saccharomyces cerevisiae antibodies in Crohn's disease patients: prevalence and diagnostic role.

ProActive Health SUPER SYNBIOTIC PACK

Veterinary Research Institute; A List of publications on Paratuberculosis..... Database maintained by the OIE Reference Laboratory for Paratruberculosis (VRI Brno) Search profile: paratuberculosis OR Johne's OR Johnes Imported from the Web of Science® database (Thomson Reuters).

Crohn's Disease and Mycobacterium Paratuberculosis A Bacteria That Infects Cattle May Have A Role In Crohn's Disease By Amber J. Tresca Updated April 13, 2012
A controversial theory is that paratuberculosis can also cause Crohn's disease in humans. In 1984, unclassified Mycobacterium strains were isolated from 3 different Crohn's patients. In 1991 it became possible to positively identify these three strains as all belonging to M paratuberculosis. In 1992 another study was conducted on intestinal tissue removed during surgery from 40 Crohn's, 23 ulcerative colitis, and 40 non-IBD patients. 65% of the Crohn's patient samples contained M paratuberculosis, contrasting with only 12.5% of non-IBD patients. The researchers concluded that M paratuberculosis does "play an etiological role in some cases of Crohn's disease".

 

Researchers test for cattle disease link in Crohn's patients 23 March 2012
Researchers at Lancaster University and the Centre for Ecology & Hydrology (CEH) are investigating the cause of a debilitating, painful condition which is on the increase, particularly among children in the UK. Professor Roger Pickup, Chair of Biomedical and Life Sciences, is leading research at Lancaster University in collaboration with Dr Glenn Rhodes at CEH and Dr Andrew Higham at Royal Lancaster Infirmary. The project is examining the link between the inflammatory bowel condition Crohn’s Disease and a harmful bacterium called Mycobacterium avium subspecies paratuberculosis (MAP), which causes Johne’s disease in a wide range of animals. Johne’s disease is particularly prevalent in sheep and cattle and has many similarities with Crohn’s Disease.

 

Is Crohn’s Disease Tied to Cattle Germ? Posted on March 1, 2012
Crohn’s disease is currently attributed to the sufferer’s own immune system attacking his digestive track. Challenging this long-standing belief is a WSU professor, Davis, who believes the disease may originate from the germ, mycobacterium avium subspecies paratuberculosis (MAP), that is found in cattle. MAP causes Johne’s disease in cows. The symptoms of Johne’s disease in cattle are similar to those experienced by sufferers of Crohn’s disease. Davis is currently working with a team of international scientists to develop a vaccine to fight the spread of the disease he believes is caused by MAP.

 

YouTube – Crohn’s Disease Maybe Linked to Beef Consumption Thursday, March 17th, 2011 at 9:42 pm with Dr. Charles Bernstein of University of Manitoba and Dr. Marcel Behr Infectious Diseases Dept. Royal Victoria Hospital, Montreal

 

Canadian Johne’s Disease Initiative What is Canadian Johne’s Disease Initiative?
Overview: The Canadian Johne’s Disease Initiative (CJDI) was created to reduce the prevalence of Johne’s Disease in Canadian herds. JD is a costly disease of ruminant animals and a potential trade barrier that affects the sustainability of livestock agriculture in Canada. JD in cattle is caused by an organism (Mycobacterium avium subspecies paratuberculosis- MAP) that may have human health implications. CJDI is a collaborative activity of industry, governments and veterinary schools, led by Dairy Farmers of Canada (DFC), the Canadian Cattlemen’s Association (CCA) and the Canadian Animal Health Coalition (CAHC)
. Also please seehttp://www.beefresearch.ca/research-topic.cfm/johnes-disease-51 for more information

 

 

 

WORLDNET DAILY Crohn's disease, sick cows and contaminated milk by Chris Bennett

Crohn's was unknown until the early 1900s when two very similar diseases were described: one in domestic animals called Johne's disease and one in humans named after the physician who first wrote about it, Dr. Burrill Crohn. Dr. H.A. Johne was the first to describe the disease in cattle.

 

ASM NEWS:

Microbes and Emerging Infections: the Compulsion To Become Something New Microbiologists
are advised to respect Koch's postulates while surveying for emerging and reemerging agents of
infectious disease Richard M. Krause

 

UK Essays: Crohn's Disease Inflammatory Intestine Crohn's Disease is a chronic inflammatory disease. In 1913 Dr. Kennedy Dalziel dealt with several patients with a disease called chronic intestinal enteritis. Chronic intestinal enteritis is found to be very similar to intestinal tuberculosis and was also believed to be a “new” disorder. Dr. Dalziel drew his attention to a recently described disease in cattle called pseudotuberculosis. Dalziel states, “the histological characters and naked-eye appearances are as similar as may be to those we have found in man. In many cases the absence of acid-fast bacilli would suggest a clear distinction, but the histological characters are so similar as to justify a proposition that the disease may be the same.”

 

Professors’ work helps detect Crohn’s, other bowel diseases By Tim Freed Senior Staff Writer Published: Sunday, April 22, 2012 Updated: Sunday, April 22, 2012 16:04              Blending their research together into one effort, two UCF faculty members have created a scientific technique that may help doctors better understand diseases. Professor Saleh Naser and Associate Professor J. Manuel Perez have developed a nanoparticle-based technique that allows doctors to effectively and quickly detect pathogens that cause Crohn’s disease and other inflammatory bowel diseases.

 

Crohn's Zone Tuesday, April 24, 2012 MAP Blood Test For Crohn's?          One news story that caught my eye was the development of a possible test for Crohns. The test lets doctors look at certain pathogens that can cause Crohn’s disease. The test works by taking blood from a Crohn’s patient and looking at microbes that often can’t be detected. One major advantage to this new test is that instead of waiting weeks or even months to treat a patient doctors can perform the test within hours. The test was created by Dr. Saleh Naser at University of Central Florida.

 

COW SHARE CANADA

 

 

THE BOVINE: First Cow Share Canada accredited raw milk farm targeted by Gov’t agents

 

 

 

April 12, 2012, Canadian Consumer Raw Advocacy Group:Keep in mind as you read this that the majority of countries where raw milk is legal require testing for MAP infected cows before their milk is ever allowed for sale. In Canada, the group Cow Share Canada, requires it’s farmers to have each and every one of their cows tested for this before they are allowed to even come onto the farm. As of this writing, there seems to be no obligation for a farmer supplying milk to be pasteurized, to have his cows tested. Once all that milk is in a common bulk tank headed for the pasteurizing plant how do we know if it’s infected or not?

 

 

Crohn's Forum: Discussion on Link between Crohn's disease and Mycobacterium paratuberculosis

 

 

Plos One 2012: Rapid and Sensitive Detection of an Intracellular Pathogen in Human Peripheral Leukocytes with Hybridizing Magnetic Relaxation Nanosensors

 

 

 

This website is an extremely informative one!!!!!!!!!!!!!

Rense.com: The Cause Of Crohn's, IBS And Most Colitis By Jeff Rense

 

 

About.com

April 13, 2012, Crohn's Disease and Mycobacterium Paratuberculosis A Bacteria That Infects Cattle May Have A Role In Crohn's Disease By Amber J. Tresca, About.com Guide Updated

 

 

 

Healthline and Crohn's Disease:

January 4, 2012: American Gastroenterological Association..............IBD emerges as a global disease .................Researchers found that the highest prevalence of IBD worldwide was reported in Canada and Europe

 

 

 

How your medicine could be draining vital nutrients from your body By CHARLOTTE DOVEY Last updated at 11:00 PM on 6th June 2011 Read more: http://www.dailymail.co.uk/health/article-1395028/How-medicine-draining-vital-nutrients-body.html

 

 

April 2011: Optimum Nutrition ENews

 

Highly Specific and Quick Detection of Mycobacterium avium subsp. paratuberculosis in Feces and Gut Tissue of Cattle and Humans by Multiple Real-Time PCR Assays J. Clin. Microbiol. May 2011 49:5 1843-1852

 

Culture Phenotypes of Genomically and Geographically Diverse Mycobacterium avium subsp. paratuberculosis Isolates from Different Hosts J. Clin. Microbiol. May 2011 49:5 1822-1830

 

 

 

March 11/2011: Crohn's Forum, Successful Treatment of a Crohn’s Disease Patient Infected With Bacteremic Mycobacterium Paratuberculosis

 

 

 

PROJECT UNCENSORED
MEDIA DEMOCRACY IN ACTION

April 30, 2010: Bacterium in Cow’s Milk May Cause Crohn’s Disease

Source: CLEVELAND FREE TIMES, June 16-22, 1999, Title: “The Crohn’s Connection?,” Author: Lisa Chamberlain Faculty Evaluator: Derek Girman, Ph.D. Student Researchers: Lisa Desmond & Julia O’Connor Mounting research shows that a bacterium in cow’s milk may cause Crohn’s disease, a debilitating chronic inflam-matory disease of the gastrointestinal tract.

 

The three articles below represent three patents on potential vaccines for map.

2010: Article: US Patent Issued on Dec. 7, 2010 for "Mycobacterium Avium Subspecies Paratuberculosis Vaccines and
Methods of Using the Same" (New Jersey Inventor) Article from:US Fed News Service, Including US State
News Article date:December 21, 2010 CopyrightCopyright © HT Media Ltd. All Rights Reserved. Provided by
ProQuest LLC. All inquiries regarding rights or concerns about this content should be directed to Customer
Support. (Hide copyright information) "The invention relates to vaccine compositions composed of at least one Mycobacterium avium subspecies paratuberculosis (MAP) antigen, or attenuated or killed MAP for use in methods of immunizing a human against a MAP infection

 

2010: ALEXANDRIA, Va., Dec. 15 -- United States Patent no. 7,851,170, issued on Dec. 14, 2010 was assigned to
United States of America as represented by the Secretary of Agriculture (Washington). "Hybridomas Producing
Highly Specific Monoclonal Antibodies to Detect Mycobacterium Avium Subspecies Paratuberculosis" was
invented by John P. Bannantine (Ames, Iowa).

 

2010: Article: US Patent Issued to Cornell Research Foundation on Dec. 28 for "Compositions for Eliciting an Immune
Response Against Mycobacterium Avium Subspecies Paratuberculosis" (New York Inventor) Article from:US
Fed News Service, Including US State News Article date:January 1, 2011CopyrightCopyright © HT Media Ltd
. All Rights Reserved. Provided by ProQuest LLC. All inquiries regarding rights or concerns about this content
should be directed to Customer Support. (Hide copyright infor
mation)

 

2010: Bovine Paratuberculosis (Johne's Disease) Information Sources Version 2.3 Updated April 05, 2010:
Purpose: The purpose is to provide links to on-line bovine paratuberculosis materials for students, for livestock
producers and for their veterinarians. Please let me know if you find materials I've overlooked or if I've made an error.
This webpage does not provide herd-specific advice and likely does not reflect the current veterinary literature or
on-line materials. I have not verified the accuracy and usefulness of these items below so you must use your own
judgment. If you are not qualified to do so, please discuss them with someone who is. If you are a producer, this should
include being familiar with your operation and the infection situation in your herd. Inclusion does not imply
endorsement nor does omission imply disapproval.
Contents: •On-Line Paratuberculosis Documents •
Calf Milk Pasteurization •State Control Programs / Information Centers •Other Relevant Sites

 

 

Gut Pathogens 2010: Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain? Ellen S Pierce

 

 

 

2009: GUT PATHOGENS: Mycobacterium avium subspecies paratuberculosis, Crohn's disease and the Doomsday Scenario John Hermon-Taylor, Gut Pathogens 2009, 1:15doi:10.1186/1757-4749-1-15, Published: 14 July 2009 Abstract (provisional) Johne's disease is chronic inflammation of the intestine caused by Mycobacterium avium subspecies paratuberculosis. Infection and disease are mainly in domestic livestock but can affect many species including primates. Johne's is a new disease which emerged at the turn of the 19th and 20th centuries and principally involved Europe and North America. It has since spread to former low incidence regions to become a global problem. Crohn's disease is a chronic inflammation of the intestine in humans which emerged in Europe and North America mid 20th century and increased to become a major healthcare problem. It has now spread to former low incidence regions. Infected animals shed Mycobacterium avium subspecies paratuberculosis in milk and into the environment. Human populations are widely exposed. Outcomes maybe influenced by microbial phenotype. Exposure to extracellular forms of these pathogens may confer some natural protection; exposure to intracellular forms which have passaged through milk macrophages or environmental protists may pose a greater threat to humans particularly individuals with an inherited or acquired susceptibility. Hot spots of human disease such as in Winnipeg which sits on rock at the junction of two rivers may result from local exposure to high levels of waterborne pathogens brought down from farmland. When appropriate methods are used most people with Crohn's disease are found to be infected. There are no data which demonstrate that these pathogens are harmless to humans. An overwhelming balance of probability and Public health risk favours the conclusion that Mycobacterium avium subspecies paratuberculosis is also pathogenic for people. A two tier co-operative pathogenic mechanism is proposed in Crohn's disease. Intracellular infection with the primary pathogen widely distributed throughout the gut causes an immune dysregulation and a specific chronic enteric neuropathy with loss of mucosal integrity. Segments of gross inflammatory disease result from the perturbed neuroimmune response to penetration into the gut wall of secondary pathogens from the lumen. These include both normal gut organisms and educated members of the enteric microbiome such as more aggressive E. coli. More new diseases may arise from failure to apply a range of remedial measures to this longstanding zoonotic problem. The complete article is available at http://www.gutpathogens.com/content/pdf/1757-4749-1-15.pdf

 

June 1, 2009 Medpage Today: DDW: Crohn's Disease Incidence Increasing in Adolescents

 

Center For Digestive Diseases

Research: Crohn's Disease research has traditionally focussed on effective therapeutic relief of inflammatory symptoms. Recent efforts have shifted towards identifying specific infectious agents that may cause the disease. By targeting the particular causative agent with certain drugs, cure of Crohn's Disease is theoretically possible. Anti-MAP. The bacterium, Mycobacterium avium paratuberculosis (MAP), is an infectious cause of Crohn’s Disease. Its causality has been proven by the standard Koch’s postulates which have been fulfilled by culturing the pathogen from patients with Crohn’s Disease, causing the disease to be reproduced in experimental animals, and then culturing back the bacterium from the experimental animals. Hence, a subset of patients with Crohn’s Disease – estimated to be around 50% - are suffering from this chronic inflammation caused by infection with MAP which is found in milk, water and foods generally. Prof John Hermon-Taylor of St George Hospital, London first used double therapy consisting of specific antibiotics Rifabutin and Clarithromycin, and obtained marked reduction inflammation in patients with Crohn’s.

 

Mycobacterium Paratuberculosis and Other Diseases by Dr. Tom Dow


 

This article covers this topic thoroughly: Great Information. PLOS PATHOGENS: Where Are All the Mycobacterium avium Subspecies paratuberculosis in Patients with Crohn's Disease? Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic granulomatous inflammation of the intestines, Johne's disease, in dairy cows and every other species of mammal in which it has been identified. MAP has been identified in the mucosal layer and deeper bowel wall in patients with Crohn's disease by methods other than light microscopy, and by direct visualization in small numbers by light microscopy. MAP has not been accepted as the cause of Crohn's disease in part because it has not been seen under the microscope in large numbers in the intestines of patients with Crohn's disease. An analysis of the literature on the pathology of Crohn's disease and on possible MAP infection in Crohn's patients suggests that MAP might directly infect endothelial cells and adipocytes and cause them to proliferate, causing focal obstruction within already existing vessels (including granuloma formation), the development of new vessels (neoangiogenesis and lymphangiogenesis), and the “creeping fat” of the mesentery that is unique in human pathology to Crohn's disease but also occurs in bovine Johne's disease. Large numbers of MAP might therefore be found in the mesentery attached to segments of intestine affected by Crohn's disease rather than in the bowel wall, the blood and lymphatic vessels running through the mesentery, or the mesenteric fat itself. The walls of fistulas might result from the neoangiogenesis or lymphangiogenesis that occurs in the bowel wall in Crohn's disease and therefore are also possible sites of large numbers of MAP. The direct visualization of large numbers of MAP organisms in the tissues of patients with Crohn's disease will help establish that MAP causes Crohn's disease.


 

Plos ONE: Linking Chronic Infection and Autoimmune Diseases: Mycobacterium avium Subspecies paratuberculosis, SLC11A1 Polymorphisms and Type-1 Diabetes Mellitus ...........Daniela Paccagnini1, Lee Sieswerda2, Valentina Rosu1, Speranza Masala1, Adolfo Pacifico3, Maria Gazouli4, John Ikonomopoulos5, Niyaz Ahmed6, Stefania Zanetti1, Leonardo A. Sechi1*


 

Mycobacterium avium subsp. paratuberculosis in powdered infant milk: F57 competitive real time PCR K. Hruska, I. Slana, P. Kralik, I. Pavlik Veterinary Research Institute, Brno, Czech Republic..............ABSTRACT: Mycobacterium avium subsp. paratuberculosis (MAP) in concentrations from 48 to 32 500 cells per gram of powdered infant milk were found in 18 out of 51 investigated samples (35%) in this study. More than 10 000 cells per gram were present in four samples (7.8%). Such concentrations mean that one package of milk contains 5 million MAP cells, which are ingested by a bottle-fed baby over the course of several days. Premature babies and bottle-fed newborns can be affected by pro-inflammatory triggers from a huge number of mycobacteria despite not suffering from infection with bacteria or viruses often linked with the etiology of Crohn’s disease. Keywords: Crohn’s disease; public health; food safety; environmental risk

 

 

Mycobacterium avium subsp. paratuberculosis in powdered infant milk:F57 competitive real time PCR K. Hruska, I. Slana, P. Kralik, I. Pavlik Veterinary Research Institute, Brno, Czech Republic........................Veterinarni Medicina, 56, 2011 (5): 226–230.......ABSTRACT: Mycobacterium avium subsp. paratuberculosis (MAP) in concentrations from 48 to 32 500 cells per gram of powdered infant milk were found in 18 out of 51 investigated samples (35%) in this study. More than 10 000 cells per gram were present in four samples (7.8%). Such concentrations mean that one package of milk contains 5 million MAP cells, which are ingested by a bottle-fed baby over the course of several days. Premature babies and bottle-fed newborns can be affected by pro-inflammatory triggers from a huge number of mycobacteria despite not suffering from infection with bacteria or viruses often linked with the etiology of Crohn’s disease

 
 
 

 

About.com: Infammatory Bowel Disease (IBD)

Know What's in Your Milk? You may be surprised at what could be in your refrigerator right now. By Amber
J. Tresca, About.com Guide Updated February 18, 2010 About.com Health's Disease and Condition content
is reviewed by the Medical Review Board
Case Reports in MedicineVolume 2010 (2010), Article ID 695461, 4 pagesdoi:10.1155/2010/695461Case Report Suspected Intestinal Tuberculosis Might Be Crohn's Disease Semiu Eniola Folaranmi,1 Gautam Mehta ,2 Debasis Datta,3 and Greg Holdstock3 ..

 

EUROPEAN COMMISSION DIRECTORATE-GENERAL HEALTH & CONSUMER PROTECTION Directorate
B - Scientific Health Opinions Unit B3 – Management of scientific committees II: Possible links between Crohn’s
disease and Paratuberculosis

 

   
 

 

Frequently asked questions on the links between mycobacteria and Crohn's disease K. Hruska and I. Pavlik Veterinary Research Institute, Brno, Czech Republic Keynote lecture delivered at the International Conference on Gastro-Intestinal Microbial Ecology, Kosice, Slovakia, 8 - 11 November 2010........A role for mycobacteria as food pathogens or immunomodulators is not yet generally accepted, although the links between them and autoinflammatory and autoimmune diseases are well documented. Their cell wall components activate inflammatory pathways and have a strong immunomodulatory potential. Links between Crohn’s disease and paratuberculosis, a mycobacterial infection of ruminants, were proposed already 97 years ago by Dalziel (1913). The clinical picture of both diseases is similar and the incidence of both is also increasing in parallel worldwide.

 


 

Bovine Paratuberculosis (Johne's Disease) Information Sources Version 2.3 Updated April 05, 2010:
Purpose: The purpose is to provide links to on-line bovine paratuberculosis materials for students, for livestock producers and for their veterinarians. Please let me know if you find materials I've overlooked or if I've made an error.

 

This webpage does not provide herd-specific advice and likely does not reflect the current veterinary literature or on-line materials. I have not verified the accuracy and usefulness of these items below so you must use your own judgment. If you are not qualified to do so, please discuss them with someone who is. If you are a producer, this should include being familiar with your operation and the infection situation in your herd. Inclusion does not imply endorsement nor does omission imply disapproval. Contents: •On-Line Paratuberculosis Documents •
Calf Milk Pasteurization •State Control Programs / Information Centers •Other Relevant Sites

 

 

Goverment of Canada: Regulations Amending the Health of Animals Regulations: December 2010

JOHNE'S DISEASE ADDED TO AMENDED HEALTH OF ANIMALS REGULATIONS ''ANNUALLY NOTIFIABLE LIST''

 

 

 

J. Dairy Sci. 93 :2371–2376 doi: 10.3168/jds.2009-2344 © American Dairy Science Association®,
2010

Lack of association between the occurrence of Crohn’s disease and occupational exposure to dairy and beef cattle herds infected with Mycobacterium avium subspecies paratuberculosis D. A. Qual ,
* J. B. Kaneene ,† T. J. Varty ,‡ R. Miller ,† and C. O. Thoen *1 * Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University,
Ames 50014 † Center for Comparative Epidemiology, College of Veterinary Medicine, Michigan State University, East Lansing 48824 ‡ USDA/APHIS/VS, Madison, WI 53711

 

FOOD FREEDOM: S 510 and Crohn’s Disease Posted on September 14, 2010 by geobear7| 10 Comments By Meryl
Williamson What if what we have been taught was clean and pure is actually filthy and even implicated in an on-going
epidemic? What if what we have been taught was dangerous to our health may actually be crucial for it?

 

 

Detection of Mycobacterium avium ss. Paratuberculosis in Blau Syndrome Tissues

C. Thomas Dow1,2 and Jay L. E. Ellingson3

 

A MAP for Crohn's Disease by author Susan Biali, MD

 

 

 

 

Suspected Intestinal Tuberculosis Might Be Crohn's disease Semiu Eniola Folaranmi,1 Gautam Mehta,2 Debasis Datta,3 and Greg Holdstock3

 

I am sure I have listed the paper below previously, but just in case you missed it, this paper by Michael Greger explains the connection between Johne's disease and Milk in a very simple way, It is definitely worth the read.

 

Paratuberculosis And Crohn's Disease: Got Milk? by Michael Greger, MD Updated January 2001

 

 

Isn't This Something!!!! I Guess They Think Animals Are More Important Than People

Veterinary college develops vaccine for Johne's disease December 8th, 2008... Johne's disease (pronounced yo-knees) is a contagious, chronic and usually fatal bacterial infection that mainly infects the small intestine of such ruminants as cattle, sheep and goats as well as farm
-raised deer, elk, llamas, alpaca, bison and zoological wildlife. Until now, the only way to prevent the disease was to identify and cull infected animals and then prevent the spread of the disease with management changes. The Cornell team identified and prepared the antigen necessary for the vaccine development. Their antigen is
licensed to the Biotechnology Research and Development Corp

Stackyard, Agriculture on the Web: 23/09/08 ...New NML Johne’s Disease Screening Programme: ............ National Milk Laboratories (NML) has launched the UK’s first Johne’s disease screening programme on milk samples. It is available to producers through their vets who can incorporate the screening as part of a farm Johne’s management plan.

 

 

 

Orkney Johne’s Disease Eradication Scheme

The Orkney Johne’s Disease Eradication Scheme (OJDES) is designed to provide a screening service for cattle, which will significantly reduce and may lead to eradication of the disease in Orkney. This scheme is all inclusive to all Orkney farmers and will be administered by the Orkney Livestock Association (OLA) who
will ensure that at least 80% of the current Orkney breeding herd is tested for the disease. OLA is a farmer-led organisation that was formed to promote animal health in Orkney. Aid provided under this scheme is granted in kind by means of subsidised services, and will not involve direct payment of money to producers. By testing over 80% of Orkney cattle, the principle aim of OJDES is to sustain disease-free, High Health status of
Orkney’s cattle

 

 

Text Interview with Marcel Behr, Chief of Infectious diseases Department, Royal Victoria Hospital, Montreal, Quebec: Gastroenterology & Hepatology Volume 4, Issue 10 October
2008 687 ...............IBD ADVANCES IN IBD
......Section Editor: Stephen B . Hanauer, MD Current Developments in the Treatment of Inflammatory Bowel Diseases Researching the Role
of Mycobacterium avium paratuberculosis in the Etiology of Crohn’s Disease Marcel A. Behr, MD, MSc
Associate Professor Centre for the Study of Host Resistance Department of Medicine McGill University

 

 

Johne's Disease Information Center

The Crohn's Connection: A Threat to be Reckoned With: Johne's disease: Challenges and Opportunities: June 2009, New Video broadcast by Michael Collins....................................This 105
minute lecture was recorded live at a meeting hosted by the Maine Veterinary Medical Association in Waterville, ME. It is the first of several presentations and covers an overview of the state of the art in Johne’s disease diagnosis and control. The presentation employs “clicker” technology allowing audience responses to questions posed on screen; a good way to test your own knowledge.

 

 

 



 

 

February 2009: Contamination of food products with Mycobacterium avium paratuberculosisa systematic review M.M. Eltholth, V.R. Marsh, S. Van Winden and F.J. GuitianDepartment of Veterinary Clinical Sciences, Royal Veterinary College, London, UK

University of Calgary:“All of the research we are doing is to improve the prevention and control of Johne’s Disease and Crohn’s Disease,” says Dr. Herman Barkema, professor of Epidemiology of Infectious Diseases at UCVM.

A H F M R: Alberta Heritage Foundation For Medical Research: Etiology of Inflammatory Bowel Disease: Gene, Microbe & Environment Interactions

April 21, 2009: AHFMR team grants: Research teams tackle pressing Alberta health concerns. A University of Calgary veterinarian will lead a diverse group of researchers looking into a serious human health problem, thanks to a new research grant from the Alberta Heritage Foundation for Medical Research (AHFMR). Dr. Herman Bark ema, from the Faculty of Veterinary Medicine, is leading a team of 22 Canadian researchers who will try and unravel the causes of inflammatory bowel disease (IBD). My heartfelt thanks to Dr. Herman Barkema from the Faculty of
Veterinary Medicine, along with U of C Faculty of Medicine’s Dr. Khrisendath (Kris) Chadee and University of Alberta’ s Dr. Richard Fedorak, are leading the Alberta IBD Consortium: Etiology of Inflammatory Bowel Disease: Gene, Microbe & Environment Interactions




www.crohnscanada.org ~ MAP-Canada ~ MAP-Canada@crohnscanada.org

Disclaimer:
MAP-Canada does not advocate a particular cause of Crohn's disease.  Our website is intended only to present evidence.  Our readers may draw their own conclusions.  We are not medical specialists and do not offer any treatment or nutritional advice.  Our mission is not to lay blame on any individual or industry, but rather to urge the Government of Canada to address the evidence presented on this site.

Mise au Point:
MAP-Canada ne recommande aucune théorie particulière sur la cause de la maladie de Crohn.L'intente de notre site Web est simplement de présenter certaineévidence mais vous pouvez arriver à vos propres conclusions.Nous ne pouvons donner de conseils de nature médicale ou alimentaire. Notre mission ne consiste aucunement à blâmer un individuou une industrie mais
plutôt à s'assurer que le Gouvernement du Canada aborde l'évidence que nous présenton

MAP-Canada would like to extend a very sincere thank you to Yanik Chicoine at www.mirweb.com for his generosity and assistance in the hosting and the mounting of this site.

MAP-Canada aimerait remercier sincèrement Yanik Chicoine a www.mirweb.com pour sons générosité et sons assistance pour l'hébergement et la programation du site.


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