Crohnscanada, Crohns disease

	COW SHARE CANADA
	THE BOVINE: First Cow Share Canada accredited raw milk farm targeted by Gov’t agents
	April 12, 2012, Canadian Consumer Raw Advocacy Group:Keep in mind as you read this that the majority of countries where raw milk is legal require testing for MAP infected cows before their milk is ever allowed for sale. In Canada, the group Cow Share Canada, requires it’s farmers to have each and every one of their cows tested for this before they are allowed to even come onto the farm. As of this writing, there seems to be no obligation for a farmer supplying milk to be pasteurized, to have his cows tested. Once all that milk is in a common bulk tank headed for the pasteurizing plant how do we know if it’s infected or not?
	Crohn's Forum: Discussion on Link between Crohn's disease and Mycobacterium paratuberculosis
	Plos One 2012: Rapid and Sensitive Detection of an Intracellular Pathogen in Human Peripheral Leukocytes with Hybridizing Magnetic Relaxation Nanosensors

	This website is an extremely informative one!!!!!!!!!!!!! Rense.com: The Cause Of Crohn's, IBS And Most Colitis By Jeff Rense
	About.com April 13, 2012, Crohn's Disease and Mycobacterium Paratuberculosis A Bacteria That Infects Cattle May Have A Role In Crohn's Disease By Amber J. Tresca, About.com Guide Updated
	Healthline and Crohn's Disease: January 4, 2012: American Gastroenterological Association..............IBD emerges as a global disease .................Researchers found that the highest prevalence of IBD worldwide was reported in Canada and Europe
	How your medicine could be draining vital nutrients from your body By CHARLOTTE DOVEY Last updated at 11:00 PM on 6th June 2011 Read more: http://www.dailymail.co.uk/health/article-1395028/How-medicine-draining-vital-nutrients-body.html
	April 2011: Optimum Nutrition ENews
	March 11/2011: Crohn's Forum, Successful Treatment of a Crohn’s Disease Patient Infected With Bacteremic Mycobacterium Paratuberculosis
	The three articles below represent three patents on potential vaccines for map. 2010: Article: US Patent Issued on Dec. 7, 2010 for "Mycobacterium Avium Subspecies Paratuberculosis Vaccines and Methods of Using the Same" (New Jersey Inventor) Article from:US Fed News Service, Including US State News Article date:December 21, 2010 CopyrightCopyright © HT Media Ltd. All Rights Reserved. Provided by ProQuest LLC. All inquiries regarding rights or concerns about this content should be directed to Customer Support. (Hide copyright information) "The invention relates to vaccine compositions composed of at least one Mycobacterium avium subspecies paratuberculosis (MAP) antigen, or attenuated or killed MAP for use in methods of immunizing a human against a MAP infection 2010: ALEXANDRIA, Va., Dec. 15 -- United States Patent no. 7,851,170, issued on Dec. 14, 2010 was assigned to United States of America as represented by the Secretary of Agriculture (Washington). "Hybridomas Producing Highly Specific Monoclonal Antibodies to Detect Mycobacterium Avium Subspecies Paratuberculosis" was invented by John P. Bannantine (Ames, Iowa). 2010: Article: US Patent Issued to Cornell Research Foundation on Dec. 28 for "Compositions for Eliciting an Immune Response Against Mycobacterium Avium Subspecies Paratuberculosis" (New York Inventor) Article from:US Fed News Service, Including US State News Article date:January 1, 2011CopyrightCopyright © HT Media Ltd . All Rights Reserved. Provided by ProQuest LLC. All inquiries regarding rights or concerns about this content should be directed to Customer Support. (Hide copyright information) 2010: Bovine Paratuberculosis (Johne's Disease) Information Sources Version 2.3 Updated April 05, 2010: Purpose: The purpose is to provide links to on-line bovine paratuberculosis materials for students, for livestock producers and for their veterinarians. Please let me know if you find materials I've overlooked or if I've made an error. This webpage does not provide herd-specific advice and likely does not reflect the current veterinary literature or on-line materials. I have not verified the accuracy and usefulness of these items below so you must use your own judgment. If you are not qualified to do so, please discuss them with someone who is. If you are a producer, this should include being familiar with your operation and the infection situation in your herd. Inclusion does not imply endorsement nor does omission imply disapproval. Contents: •On-Line Paratuberculosis Documents • Calf Milk Pasteurization •State Control Programs / Information Centers •Other Relevant Sites
	Gut Pathogens 2010: Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain? Ellen S Pierce
	2009: GUT PATHOGENS: Mycobacterium avium subspecies paratuberculosis, Crohn's disease and the Doomsday Scenario John Hermon-Taylor, Gut Pathogens 2009, 1:15doi:10.1186/1757-4749-1-15, Published: 14 July 2009 Abstract (provisional) Johne's disease is chronic inflammation of the intestine caused by Mycobacterium avium subspecies paratuberculosis. Infection and disease are mainly in domestic livestock but can affect many species including primates. Johne's is a new disease which emerged at the turn of the 19th and 20th centuries and principally involved Europe and North America. It has since spread to former low incidence regions to become a global problem. Crohn's disease is a chronic inflammation of the intestine in humans which emerged in Europe and North America mid 20th century and increased to become a major healthcare problem. It has now spread to former low incidence regions. Infected animals shed Mycobacterium avium subspecies paratuberculosis in milk and into the environment. Human populations are widely exposed. Outcomes maybe influenced by microbial phenotype. Exposure to extracellular forms of these pathogens may confer some natural protection; exposure to intracellular forms which have passaged through milk macrophages or environmental protists may pose a greater threat to humans particularly individuals with an inherited or acquired susceptibility. Hot spots of human disease such as in Winnipeg which sits on rock at the junction of two rivers may result from local exposure to high levels of waterborne pathogens brought down from farmland. When appropriate methods are used most people with Crohn's disease are found to be infected. There are no data which demonstrate that these pathogens are harmless to humans. An overwhelming balance of probability and Public health risk favours the conclusion that Mycobacterium avium subspecies paratuberculosis is also pathogenic for people. A two tier co-operative pathogenic mechanism is proposed in Crohn's disease. Intracellular infection with the primary pathogen widely distributed throughout the gut causes an immune dysregulation and a specific chronic enteric neuropathy with loss of mucosal integrity. Segments of gross inflammatory disease result from the perturbed neuroimmune response to penetration into the gut wall of secondary pathogens from the lumen. These include both normal gut organisms and educated members of the enteric microbiome such as more aggressive E. coli. More new diseases may arise from failure to apply a range of remedial measures to this longstanding zoonotic problem. The complete article is available at http://www.gutpathogens.com/content/pdf/1757-4749-1-15.pdf
	June 1, 2009 Medpage Today: DDW: Crohn's Disease Incidence Increasing in Adolescents
	Center For Digestive Diseases Research: Crohn's Disease research has traditionally focussed on effective therapeutic relief of inflammatory symptoms. Recent efforts have shifted towards identifying specific infectious agents that may cause the disease. By targeting the particular causative agent with certain drugs, cure of Crohn's Disease is theoretically possible. Anti-MAP. The bacterium, Mycobacterium avium paratuberculosis (MAP), is an infectious cause of Crohn’s Disease. Its causality has been proven by the standard Koch’s postulates which have been fulfilled by culturing the pathogen from patients with Crohn’s Disease, causing the disease to be reproduced in experimental animals, and then culturing back the bacterium from the experimental animals. Hence, a subset of patients with Crohn’s Disease – estimated to be around 50% - are suffering from this chronic inflammation caused by infection with MAP which is found in milk, water and foods generally. Prof John Hermon-Taylor of St George Hospital, London first used double therapy consisting of specific antibiotics Rifabutin and Clarithromycin, and obtained marked reduction inflammation in patients with Crohn’s. Mycobacterium Paratuberculosis and Other Diseases by Dr. Tom Dow
	This article covers this topic thoroughly: Great Information. PLOS PATHOGENS: Where Are All the Mycobacterium avium Subspecies paratuberculosis in Patients with Crohn's Disease? Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic granulomatous inflammation of the intestines, Johne's disease, in dairy cows and every other species of mammal in which it has been identified. MAP has been identified in the mucosal layer and deeper bowel wall in patients with Crohn's disease by methods other than light microscopy, and by direct visualization in small numbers by light microscopy. MAP has not been accepted as the cause of Crohn's disease in part because it has not been seen under the microscope in large numbers in the intestines of patients with Crohn's disease. An analysis of the literature on the pathology of Crohn's disease and on possible MAP infection in Crohn's patients suggests that MAP might directly infect endothelial cells and adipocytes and cause them to proliferate, causing focal obstruction within already existing vessels (including granuloma formation), the development of new vessels (neoangiogenesis and lymphangiogenesis), and the “creeping fat” of the mesentery that is unique in human pathology to Crohn's disease but also occurs in bovine Johne's disease. Large numbers of MAP might therefore be found in the mesentery attached to segments of intestine affected by Crohn's disease rather than in the bowel wall, the blood and lymphatic vessels running through the mesentery, or the mesenteric fat itself. The walls of fistulas might result from the neoangiogenesis or lymphangiogenesis that occurs in the bowel wall in Crohn's disease and therefore are also possible sites of large numbers of MAP. The direct visualization of large numbers of MAP organisms in the tissues of patients with Crohn's disease will help establish that MAP causes Crohn's disease.
	Plos ONE: Linking Chronic Infection and Autoimmune Diseases: Mycobacterium avium Subspecies paratuberculosis, SLC11A1 Polymorphisms and Type-1 Diabetes Mellitus ...........Daniela Paccagnini1, Lee Sieswerda2, Valentina Rosu1, Speranza Masala1, Adolfo Pacifico3, Maria Gazouli4, John Ikonomopoulos5, Niyaz Ahmed6, Stefania Zanetti1, Leonardo A. Sechi1*
	Mycobacterium avium subsp. paratuberculosis in powdered infant milk: F57 competitive real time PCR K. Hruska, I. Slana, P. Kralik, I. Pavlik Veterinary Research Institute, Brno, Czech Republic..............ABSTRACT: Mycobacterium avium subsp. paratuberculosis (MAP) in concentrations from 48 to 32 500 cells per gram of powdered infant milk were found in 18 out of 51 investigated samples (35%) in this study. More than 10 000 cells per gram were present in four samples (7.8%). Such concentrations mean that one package of milk contains 5 million MAP cells, which are ingested by a bottle-fed baby over the course of several days. Premature babies and bottle-fed newborns can be affected by pro-inflammatory triggers from a huge number of mycobacteria despite not suffering from infection with bacteria or viruses often linked with the etiology of Crohn’s disease. Keywords: Crohn’s disease; public health; food safety; environmental risk
	Project no.: 007081:Project acronym:PathogenCombat Project title: Control and prevention of emerging and future pathogens at cellular and molecular level throughout the food chain Instrument: Integrated Project (IP) Thematic Priority 5 – Food Quality and Safety Detection and absolute quantification of Mycobacterium avium subspecies paratuberculosis by real time qPCR in milk, cheese, yoghurt and tissue Summary of protocols developed within PathogenCombat
	Mycobacterium avium subsp. paratuberculosis in powdered infant milk:F57 competitive real time PCR K. Hruska, I. Slana, P. Kralik, I. Pavlik Veterinary Research Institute, Brno, Czech Republic........................Veterinarni Medicina, 56, 2011 (5): 226–230.......ABSTRACT: Mycobacterium avium subsp. paratuberculosis (MAP) in concentrations from 48 to 32 500 cells per gram of powdered infant milk were found in 18 out of 51 investigated samples (35%) in this study. More than 10 000 cells per gram were present in four samples (7.8%). Such concentrations mean that one package of milk contains 5 million MAP cells, which are ingested by a bottle-fed baby over the course of several days. Premature babies and bottle-fed newborns can be affected by pro-inflammatory triggers from a huge number of mycobacteria despite not suffering from infection with bacteria or viruses often linked with the etiology of Crohn’s disease
	Excellent Blog/Beating Crohn's. This blog explains the link between Crohn's disease and Mycobacterium Paratuberculosis extremely well.
	MAJOR SCIENTIFIC BREAKTHROUGH!!!!!!!!!!!!!!!!!!!!!!!!!!!Email received from Tim Page of The Chronic Crohns Campaign Wikipedia: Mycobacterium avium subspecies paratuberculosis Map causes Johne's disease in cattle and other ruminants, and it has long been suspected as a causative agent in Crohn's disease in humans[3]; this connection is controversial.[4] Recent studies have shown that Map present in milk can survive pasteurization, which has raised human health concerns due to the widespread nature of Map in modern dairy herds. Map is heat resistant and it is capable of sequestering itself inside white blood cells, which may contribute to its persistence in milk. It has also been reported to survive chlorination in municipal water supplies
	About.com: Infammatory Bowel Disease (IBD) Know What's in Your Milk? You may be surprised at what could be in your refrigerator right now. By Amber J. Tresca, About.com Guide Updated February 18, 2010 About.com Health's Disease and Condition content is reviewed by the Medical Review Board Case Reports in MedicineVolume 2010 (2010), Article ID 695461, 4 pagesdoi:10.1155/2010/695461Case Report Suspected Intestinal Tuberculosis Might Be Crohn's Disease Semiu Eniola Folaranmi,1 Gautam Mehta ,2 Debasis Datta,3 and Greg Holdstock3 .. EUROPEAN COMMISSION DIRECTORATE-GENERAL HEALTH & CONSUMER PROTECTION Directorate B - Scientific Health Opinions Unit B3 – Management of scientific committees II: Possible links between Crohn’s disease and Paratuberculosis